Synthesis of β-Heteroaryl Propionates via Trapping of Carbocations with π-Nucleophiles.
نویسندگان
چکیده
A variety of heterocyclic alcohols and acetates were coupled with silyl ketene acetals and other π-nucleophiles in the presence of trimethylsilyl trifluoromethanesulfonate to provide an array of substituted β-heteroaryl propionates, including those with contiguous quaternary centers, as well as vinylogs thereof. This reaction also proceeds with high diastereoselectivity when the π-nucleophile bears a chiral auxiliary.
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ورودعنوان ژورنال:
- Tetrahedron letters
دوره 50 26 شماره
صفحات -
تاریخ انتشار 2009